NCAA Football Week 6 Preview: Matchups to Watch

This Saturday, college football fans are in for a treat as Week 6 of the 2025 season unfolds across the country. While there aren’t many ranked matchups, there are plenty of games that have the potential to shake things up in the national landscape.

The action kicks off at noon with No. 14 Iowa State taking on a revitalized Cincinnati team. This clash features two standout quarterbacks: Rocco Becht for Iowa State and Brendan Sorsby for Cincinnati, making it a game to keep an eye on.

Later in the afternoon, No. 7 Penn State and No. 9 Texas both hit the road for crucial conference games against UCLA and Florida, respectively. In Tuscaloosa, no. 10 Alabama will host No. 16 Vanderbilt in one of the few ranked matchups of the day. Meanwhile, No. 21 Notre Dame will welcome Boise State, with both teams competing after being part of the 2024 College Football Playoffs.

As the sun sets, all eyes will be on the ACC rivalry showdown between No. 3 Miami and No. 18 Florida State. This game not only revives an age-old rivalry but also holds significant implications for conference standings.

Don’t forget about Houston, which remains unbeaten but is not in the AP Top 25. The Cougars are set to host No. 11 Texas Tech, a matchup with strong upset potential.

As kickoff approaches, analysts have made their picks. For instance, they suggest an under bet for the Navy vs. Air Force game due to both teams’ slow-paced play. Meanwhile, the predictions for the Notre Dame vs. Boise State game lean towards an over on the point total, expecting plenty of action given the offensive capabilities on display.

Whether you’re cheering for your favorite team or keeping tabs on the upsets, Week 6 promises to deliver excitement as teams battle on the field.