As the excitement builds in San Francisco, the 49ers are facing a bit of a hurdle just days before their season opener. Concerns have emerged regarding running back Christian McCaffrey, who has been listed as limited due to a calf injury in the team’s practice report from Thursday. This is a concerning update considering he had no injury concerns noted in the report from the day before.

The 49ers are set to kick off their season against the Seattle Seahawks this Sunday. Fans were hopeful as McCaffrey had been reported healthy throughout the offseason. However, with this latest news, optimism may now be tempered. McCaffrey has had a history of injuries, notably missing 13 games last season due to issues with his calf and knee. While he was explosive during the 2023 season, winning a running title, any setback carries weight given his past.

Notably, Thursday is typically when McCaffrey addresses the media, but he was absent this time, further fueling worry among fans and analysts alike. The situation will be closely monitored as the days progress, with many eager to see how serious this calf injury might be before their big matchup.

Meanwhile, excitement wasn’t limited to San Francisco. In a thrilling season opener, the Philadelphia Eagles held off the Dallas Cowboys in the 2025 NFL Kickoff Game. The contest was temporarily suspended due to thunderstorms, a move that added an unusual twist to the night. During this game, a notable incident occurred when Eagles defensive tackle Jalen Carter was ejected for an altercation involving Dak Prescott.

In other league news, Amari Cooper of the Raiders has announced his intention to retire from football. This surprising decision has left fans and teammates alike in shock. Additionally, the Kansas City Chiefs and Los Angeles Chargers are gearing up for a historic showdown in São Paulo, Brazil, marking the NFL’s return to South America.

As the 2025 season progresses, the spotlight will remain on the 49ers and McCaffrey, with fans hoping for a quick recovery as they prepare for kickoff against their rivals.